Screenshot shows intraprocedural visualization of imaging for needle position confirmation for transperineal prostate biopsy in a 71-year-old man with no rectal access and increasing PSA (31.09 ng/dL [31.09 μg/L]). Targeted biopsy yielded Gleason 4+3 PCa in right anterior central gland. Image shows 3D Slicer targeting module during biopsy with needle confirmation image loaded. Left: control panel. Top middle: axial T2-weighted MR image. Top right: three-dimensional view, including calculated needle path (arrow). Bottom middle: sagittal T2-weighted MR image shows target and needle tract. Bottom right: coronal T2-weighted MR image, with target and needle track. RGC = right central gland.
Magnetic Resonance Image-guided interventions have enormous potential to improve and advance the care of men with prostate cancer. However, there are clear limitations with the current methods of both prostate cancer diagnosis and treatment. If non-invasive imaging can identify suspicious tumor foci in the gland with greater specificity, it may be used to direct more accurate prostate biopsies. A non-invasive biomarker of the tumor and its possible recurrence, combined with Prostate Specific Antigen detection methods would be a very powerful alternative to biopsy.